R&D Intern

Job Description

About Legend Biotech

Legend Biotech is a global biotechnology company committed to treating, and ultimately curing, life-threatening diseases. Headquartered in Somerset, New Jersey, the company specializes in developing advanced cell therapies across a diverse array of technology platforms. These include autologous and allogenic chimeric antigen receptor T-cell (CAR-T), T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. With three R&D sites worldwide, Legend Biotech applies innovative technologies to discover safe, efficacious, and cutting-edge therapeutics for patients globally.

Legend Biotech has also established a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). This strategic partnership aims to combine the strengths and expertise of both companies to advance the promise of immunotherapy in the treatment of multiple myeloma.

R&D Intern

Location: Philadelphia, PA

Legend Biotech is seeking an R&D Intern to join the Research & Early Development team in Philadelphia, PA.

Role Overview

The R&D Intern will provide essential support to research activities primarily focused on cellular therapy and CAR-T technology. This dynamic role involves detailed analysis of the cytotoxic potential of CAR-T cells and other immune cells, comprehensive cytokine analysis, and the correlation of data across various donor variabilities. The intern will also play a key part in evaluating T cells generated with in-vivo CAR platforms and contribute significantly to data analysis and reporting.

Key Responsibilities

• Perform cytotoxicity assays and cytokine analysis utilizing MSD assay technology.
• Analyze CAR-T cells, macrophages, and various other immune cells to determine their cytotoxic potential.
• Correlate cytotoxicity data across multiple donors to identify trends and significant findings.
• Support the evaluation of in-vivo CAR platform performance and efficacy.
• Analyze experimental data thoroughly and prepare clear, concise reports for managers and the wider team.
• Maintain accurate and detailed laboratory records, ensuring strict adherence to Standard Operating Procedures (SOPs).

Requirements

• Currently enrolled as a college student (BS, MS, or PhD) in a relevant field such as Life Science, Biomedical Science, Biotechnology, Cell Science, Biology, Virology, Molecular Biology, or any STEM discipline.
• Desired Academic Grade Level: Junior, Senior, or Graduate Student.
• Demonstrated interest in cellular therapy and immunotherapy.
• Preferred Knowledge: Familiarity with CAR-T technology, virus design, or immune cell assays.
• Ability to commit to a balanced work distribution: approximately 70% lab bench work and 30% desk work.
• Possesses strong communication and organizational skills.

Skills You’ll Gain

• Hands-on experience in cutting-edge CAR-T cell culture and transduction techniques.
• Exposure to the development processes of in-vivo CAR platforms.
• A deep understanding of various immunotherapy approaches and associated assay techniques.

Please note: These benefits are offered exclusively to permanent full-time employees. Contract employees are not eligible for benefits through Legend Biotech.

EEO Statement

It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.

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